Molekulaarisen biotekniikan ja diagnostiikan linjan julkaisut
/ Molecular Biotechnology and Diagnostics publications
Molekulaarisen biotekniikan ja diagnostiikan linja /
Molecular Biotechnology and Diagnostics 2009
Väitöskirjat / Doctoral theses 2009 [sivun alkuun / page top]
Hagren, V. 2009: Food safety testing: Rapid molecular methods for chemical and biological hazards. Annales Universitatis Turkuensis AI 397. 102 s. [a]
Jääskeläinen, A. 2009: Design and production of protein nanostructures for biomolecular Detection. Annales Universitatis Turkuensis AI 393. 108 s. [a]
Kokko, T. 2009: Lanthanide chelates as donors in fluorescence resonance energy transfer: Exciting prospects for bioaffinity assay detection. Annales Universitatis Turkuensis AI 398. 94 s. [a]
Valanne, A. 2009: Nanoparticle labels in bioaffinity assays. Annales Universitatis Turkuensis AI 390. 111 s. [a]
Wittfooth, S. 2009: Free PAPP-A: a novel marker in acute coronary syndrome patients. Annales Universitatis Turkuensis AI 402, 120 s. [a]
Ylikotila, J. 2009: Highly functional binding surface for miniaturised solid-phase immunoassays -A spot story-. Annales Universitatis Turkuensis AI 391. 106 s. [a]
Muu tieteellinen julkaisutoiminta / Other scientific publications 2009
Helo P*, Cronin AM*, Danila DC*, Wenske S*, Gonzalez-Espinoza R*, Anand A*, Koscuiszka M*, Väänänen RM, Pettersson K, Chun FK*, Steuber T*, Huland H*, Guillonneau BD*, Eastham JA*, Scardino PT*, Fleisher M*, Scher HI*, Lilja H*. Circulating prostate tumor cells detected by reverse transcription-PCR in men with localized or castration-refractory prostate cancer: concordance with CellSearch assay and association with bone metastases and with survival. Clin Chem. 2009 Apr;55(4):765-73. Epub 2009 Feb 20. PubMed PMID: 19233911. [C]
Jääskeläinen, A., Soukka, T., Lamminmäki, U., Korpimäki, T., Virta*, M. 2009: Development of a Denatura-tion/Renaturation-Based Production Process for Ferritin Nanoparticles. Biotechnology and Bioengineering 102: 1012-1024. [C]
Kiviniemi M., Ilonen J., Lövgren T.,: A homogeneous HLA-B*27 genotyping assay using dried reagent mixtures. Dis Markers 2009;27(2):85-91. PubMed PMID: 19893203. [C]
Kokko, T., Kokko, L., Soukka, T. 2009: Terbium(III) Chelate as an Efficient Donor for Multiple-Wavelength Fluores-cent Acceptors. Journal of Fluorescence 19: 159-164. [C]
Latva-Hirvelä J, Kytö V, Saraste A, Eriksson S, Vuorinen T, Pettersson K, Saukko P. Development of troponin autoantibodies in experimental coxsackievirus B3 myocarditis. Eur J Clin Invest. 2009 Jun;39(6):457-62. Epub 2009 Apr 8. PubMed PMID: 19397694. [C]
Näreoja, T., Vehniäinen, M., Lamminmäki, U., Hänninen, P.E. & Härmä H. 2009: Study on nonspecificity of an immuoassay using Eu-doped polystyrene nanoparticle labels. Journal of Immunological Methods 345(1-2):80-9. [C]
Pettersson K, Eriksson S*, Wittfooth S, Engström E, Nieminen M*, Sinisalo J*. Autoantibodies to cardiac troponin associate with higher initial concentrations and longer release of troponin I in acute coronary syndrome patients. Clin Chem. 2009 May;55(5):938-45. Epub 2009 Mar 5. PubMed PMID: 19264856. [C]
Rantanen, T., Järvenpää, M.-L., Vuojola, J., Arppe, R., Kuningas, K. Soukka, T. 2009: Upconverting phosphors in a dual-parameter LRET-based hybridization assay. – Analyst 134(8): 1713–1716. [C]
Saketi*, P., Kreutzer*, J., Niemelä, K., Välimaa, L. & Kallio*, P. 2009: Automated modular bacterial filtering system with embeddable microfluidic chips. Automation Science and Engineering, 2009. CASE 2009. IEEE International Conference on, 22-25 Aug. 2009, pp. 212 - 216. [D].
Tertti R, Wittfooth S, Porela P, Airaksinen KE, Metsärinne K, Pettersson K. Intravenous administration of low molecular weight and unfractionated heparin elicits a rapid increase in serum pregnancy-associated plasma protein A. Clin Chem. 2009 Jun;55(6):1214-7. Epub 2009 Mar 26. PubMed PMID: 19325014. [C]
Valanne, A., Suojanen, J., Peltonen*, J., Soukka, T., Hänninen, P., Härmä, H. 2009: Multiple sized europium(III) chelate-dyed polystyrene particles as donors in FRET - an application for sensitive protein quantification utilizing competitive adsorption. Analyst 134: 980-986. [C]
Valta MP, Tuomela J, Vuorikoski H, Loponen N, Väänänen RM, Pettersson K, Väänänen HK, Härkönen PL. FGF-8b induces growth and rich vascularization in an orthotopic PC-3 model of prostate cancer. Journal of Cellular Biochemistry. 2009 Jul 1;107(4):769-84. PubMed PMID: 19415685. [C]
Vickers AJ*, Wolters T*, Savage CJ*, Cronin AM*, O'Brien MF*, Pettersson K, Roobol MJ*, Aus G*, Scardino PT*, Hugosson J*, Schröder FH*, Lilja H*. Prostate-Specific Antigen Velocity for Early Detection of Prostate Cancer: Result from a Large, Representative, Population-based Cohort. Eur Urol. 2009 Aug 7. [Epub ahead of print] PubMed PMID: 19682790. [C]
Vuojola, J., Lamminmäki, U., Soukka, T., 2009: Resonance Energy Transfer from Lanthanide Chelates to Overlapping and Nonoverlapping Fluorescent Protein Acceptors. Analytical Chemistry 81(12): 5033-5038. [C]
Ylikotila J, Välimaa L, Takalo H, Pettersson K. 2009: Improved surface stability and biotin binding properties of streptavidin coating on polystyrene. Colloids and Surfaces B: Biointerfaces. 2009 May 1;70(2):271-7. Epub 2009 Jan 9. PubMed PMID: 19181493. [C]
Patentit:
Eriksson S*, Pettersson K, 2009: Immunoassay. United States Patent US7,638,292 B2. [K]
Huovinen T, Lamminmäki U, Brockaman E-C, Vehniäinen M, 2009: Mutagenesis method. National patent application FI200996371. [K]
Soukka T, Lamminmäki U, 2009: Luminescence Assay Method (Switch). National patent application FI20095302. [K]
Molekulaarisen biotekniikan ja diagnostiikan linja /
Molecular Biotechnology and Diagnostics 2008
Väitöskirjat / Doctoral theses 2008 [sivun alkuun / page top]
Välimaa L. 2008: Streptavidin – A versatile binding protein for solid-phase immunoassays. Turun yliopiston julkaisuja Annales Universitatis Turkuensis Sarja A1, 135 s.
Muu tieteellinen julkaisutoiminta / Other scientific publications 2008
*Alviggi C., *Clarizia R., Pettersson K., *Mollo A., *Humaidan P., *Strina I., *Coppola M., *Ranieri a., *D´Uva M., *De Placido G. 2008: Suboptimal response to GnRHa long protocol is associated with a common LH polymorphism. Reproductive BioMedicine vol 18 no 1, 9-14. [C]
*Guglielmetti S., *Tamagnini I., *Mora D., *Minuzzo M., *Scarafoni A., *Arioli S., Hellman J., *Karp M., *Parini C. 2008: Implication of an outer surface lipoprotein in adhesion of Bifidobacterium bifidum to caco-2 cells. Applied and Environmental Microbiology vol 74, no15, 4695-4702. [C]
Hagrèn V.,* Lode P., *Syrjälä A., Soukka T., Lövgren T.,*Kojola H., *Nurmi J. 2008: An automated PCR platform with homogenous time-resolved fluorescence detection and dry chemistry assay kits. – Analytical Biochemistry 374:411-416 [C]
Hagrén V., *von Lode P., *Syrjälä A., *Korpimäki T., *Tuomola M., Kauko O., *Nurmi J. 2008: An 8-hour system for salmonella detection with immunomagnetic separation and homogeneous time-resolved fluorescence PCR. Int J Food Microbiol 125: 158-161. [C]
Hellman J. 2008: Stabilization of thin-layer agarose gels after isoelectric focusing with polyacrylamide enables reverse imidazole-zinc staining and facilitates two-dimensional gel electrophoresis. Anal bioanal Chem 392:239-245. [C]
Huhtinen, P., *Kivelä, M., Soukka, T., *Tenhu, H., Lövgren, T., ja Härmä, H. 2008: Preparation, characterisation, application of europium(III) chelate -dyed polystyrene-acrylic acid nanoparticle labels. Analytica Chimica Acta 630: 211-216 [C]
*Huet AC, *Charlier C, *Singh G, *Godefroy SB, Leivo J, Vehniäinen M, *Nielen MW, *Weigel S, *Delahaut P. 2008: Development of an optical surface plasmon resonance biosensor assay for (fluoro)quinolones in egg, fish, and poultry meat. - Analytica Chimica Acta 632(2):195-203 [C]
Hyppänen, I., Hölsä, J., Kankare, J., Lastusaari, M., Pihlgren, L., ja Soukka, T. 2008: Defect structure and up-conversion luminescence properties of ZrO2: Yb3+,Er3+ nanomaterials. Journal of Fluorescence 18: 1029-1034 [C]
Ilva T, Lund J, Porela P,* Mustonen H, *Voipio-Pulkki LM, *Eriksson S, Pettersson K, *Tanner P, *Pulkki K. 2008: Early markers of myocardial injury: cTnI is enough. Clin Chim Acta. 2008 Nov 1. [Epub ahead of print] PMID: 18992232 [PubMed - as supplied by publisher] [C]
*Järås, K., *Tajudin, A. A., *Ressine, A., Soukka, T., *Marko-Varga, G., *Bjartell, A., *Malm, J., *Laurell, T., ja *Lilja, H. 2008: ENSAM: Europium nanoparticles for signal enhancement of antibody microarrays on nanoporous silicon. Journal of Proteome Research 7: 1308-1314 [C]
Jääskeläinen, A., Harinen, R-R., Soukka, T., Lamminmäki, U., Korpimäki, T., ja *Virta, M. 2008: Biologically produced bifunctional recombinant protein nanoparticles for immunoassays. Analytical Chemistry 80: 583-587 [C]
*Kallio P., Välimaa L., *Vahimaa P. 2008: Uusia laboratoriotestejä nanotekniikoin. Nopeutta ja herkkyyttä diagnostiikkaan. Prosessori 11 [i]
Kokko, L., Kokko, T., Lövgren, T., ja Soukka, T. 2008: Particulate and soluble Eu(III)-chelates as donor labels in homogeneous fluorescence resonance energy transfer based immunoassay. Analytica Chimica Acta 606: 72-79 [C]
*Miettinen KH, *Eriksson S, *Magga J, *Tuomainen P,* Kuusisto J, *Vanninen EJ,
*Turpeinen A, *Punnonen KR, Pettersson K,*Peuhkurinen KJ. 2008: Clinical significance of troponin I efflux and troponin autoantibodies in patients with dilated cardiomyopathy. J Card Fail. 2008 Aug;14(6):481-8. Epub 2008 May 27. PMID: 18672196 [PubMed - in process] [C]
*Nevanen,T., *Munck, N., Lamminmäki, U., In book " Computational Structural Biology" (World Scientific Publishing, 2008) Chapter 16. Computational Antibody Engineering. ISBN-13 978-981-277-877-2, ISBN-10 981-277-877-2 [H]
Rantanen, T., Järvenpää, M-L., Vuojola, J., Kuningas, K., ja Soukka, T. 2008: Fluorescence-quenching-based enzyme-activity assay by using photon upconversion. Angewandte Chemie International Edition English 47: 3811-3813 [C]
Soukka, T., Rantanen, T., ja Kuningas, K. 2008: Photon upconversion in homo-geneous fluorescence-based bioanalytical assays. Annals of the New York Academy of Sciences 1130: 188-200 [C]
Valanne A., Malmi P., Appelblom H., *Niemelä P., Soukka T. 2008: A dual-step fluorescence resonance energy transfer-based quenching assay for screening of caspase-3 inhibitors. – Analytical Biochemistry 375:71-78 [C]
*Wenske S, *Korets R, *Cronin AM, *Vickers AJ, *Fleisher M, *Scher HI, Pettersson K, *Guillonneau B,* Scardino PT,* Eastham ja *Lilja H. 2008: Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy. Int J Cancer. 2008 Sep 9;124(3):659-663. [Epub ahead of print] PMID: 19003994 [PubMed - as supplied by publisher] [C]
*Vickers AJ, *Cronin AM, *Aus G,* Pihl CG,* Becker C, Pettersson K, *Scardino PT, *Hugosson J,* Lilja H. 2008: A panel of kallikrein markers can reduce unnecessary biopsy for prostate cancer: data from the European Randomized Study of Prostate Cancer Screening in Göteborg, Sweden. BMC Med. 2008 Jul 8;6:19. PMID: 18611265 [PubMed - indexed for MEDLINE] [C]
Wittfooth S., Qin Q-P., Pettersson K. 2008: Performance of immunofluorometric point-of-care assays for free pregnancy-associated plasma protein A detection in whole blood samples. – Clinical Chemistry Laboratory Medicine 46(1):18-20 PMID: 17663635 [PubMed – in process] [C]
Välimaa L, Ylikotila J, *Kojola H., Soukka T., *Takalo H., Pettersson K. 2008: Streptavidin-coated spot surfaces for sensitive immunoassays using fluorescence surface readout. Anal bioanal Chem 391:2135-2144 [C]
Väänänen R-M., Rissanen M., Kauko O., Junnila S., Väisänen V., *Nurmi J., *Alanen K., Nurmi M., Pettersson K. 2008: Quantitative real-time RT-PCR assay for PCA3. Clinical Biochemistry 41:103-108 [C]
Molekulaarisen biotekniikan ja diagnostiikan linja /
Molecular Biotechnology and Diagnostics 2007
Väitöskirjat / Doctoral theses 2007 [sivun alkuun / page top]
Kokko L. 2007: Eu(III)-chelate dyed nanoparticles: Radiant label technology for homogeneous assays. Annales Universitatis Turkuensis A I 369, 116 [a]
Kuningas K. 2007: Towards photoluminescence-based homogenous immunoassays in whole blood: Upconverting inorganic lanthanide phosphors as novel reporters. Annales Universitatis Turkuensis A I 364, 124 s [a]
Väisänen V. 2007: Measurement of human glandular kallikrein 2. Annales Universitatis Turkuensis A I, 361, 133 s. [a]
Muu tieteellinen julkaisutoiminta / Other scientific publications 2007
Appelblom H., Nurmi J., Soukka T., *Pasternack M., Penttilä K.E., Lövgren T., Niemelä P. 2007: Homogeneous TR-FRET high-throughput screening assay for calcium-dependent multimerization of sorcin. - Journal of Biomolecular Screening 12 (6): 842-848. [C]
*Birken S., *McChesney R., *Yershova O., *Gaughan J., Pettersson K., *Rechenberg G., *Wu CH., *Taliadouros G. 2007: Patterns of LHbetacf among women in health and disease. - Molecular and Cellular Endocrinology 260-262:172-82. [C]
*Gerdhem P., Ivaska KK., *Isaksson A., Pettersson K., VäänänenHK., *Obrant KJ., *Åkesson K. 2007: Associations Between Homocysteine, Bone Turnover, BMD, Mortality and Fracture Risk in Elderly Women. - Journal of Bone and Mineral Research 22 (1):127-134. [C]
Hellman J. 2007: Polyacrylamide lamination enables mass spectrometry compatible staining and in-gel digestion of proteins separated by agarose IEF. - Proteomics 7:3441-3444. [C]
Härmä H., Soukka T., Shavel A.,*Gaponik N., *Weller H. 2007: Luminescent energy transfer between cadmium telluride nanoparticle and lanthanide(III) chelate in competitive bioaffinity assays of biotin and estradiol. - Analytica Chimica Acta 604:177-183. [C]
Jaakohuhta S., Härmä H., *Tuomola M., Lövgren T. 2007: Sensitive Listeria spp. Immunoassay based on europium(III) nanoparticulate labels using time-resolved fluorescence. - International Journal of Food Microbiology 114: 288-294. [C]
Jääskeläinen A., Harinen R.R., Lamminmäki U., Korpimäki T., Pelliniemi L.J., Soukka T., Virta M. 2007: Production of apoferritin-based bioinorganic hybrid nanoparticles by bacterial fermentation followed by self-assembly. - Small 3 (8):1362-1367. [C]
Kiviniemi M., Hermann R., *Nurmi J., *Ziegler AG., *Knip M., Simell O., *Veijola R., Lövgren T., Ilonen J., the Teddy Study Group 2007: A high-throughput population screening system for the estimation of genetic risk for type I diabetes: An application for the TEDDY (The Environmental Determinants of Diabetes in the Young) study. - Diabetes Technology & Therapeutics 9 (5): 460-472. [C]
Kokko L., Lövgren T., Soukka T. 2007: Europium(III)-chelates embedded in nanoparticles are protected from interfering compounds present in assay media. - Analytica Chimica Acta 585:17-23. [C]
Kokko T., Kokko L,. Soukka T, Lövgren T. 2007: Homogenous non-competetive bioaffinity assay based on fluorescence resonance energy transfer. - Analytica Chimica Acta 585:120-125. [C]
KokkoT., Kokko L., Lövgren T., Soukka T. 2007: Homogenous noncompetitive immunoassay for 17ß-estradiol based on fluorescence resonance energy transfer. - Analytical Chemistry 79: 5935-5940. [C]
Kuningas K., Päkkilä H., Ukonaho T., Rantanen T., Lövgren T., Soukka T. 2007: Upconversion fluorescence enables homogenous immunoassay in whole blood. - Clinical Chemistry 53 (1):145-146. [C]
Kuningas K., Päkkilä H., Lövgren T., Soukka T. 2007: Effect of blood on the measurement of upconversion fluorescence. - Clinical Chemistry Laboratory Medicine 45: S196. [D]
Kuningas K., Niemi I., Päkkilä H., Pettersson K., Lövgren T. 2007: Sensitive cardiac troponin I immunoassay using europium(III) chelate-dyed nanoparticles as reporters. - Clinical Chemistry Laboratory Medicine 45: S236. [D]
Kuningas K., Niemi I., *Hedberg P., Päkkilä H., Pettersson K., Lövgren T. 2007: A sensitive troponin I immunoasay using europium(III) chelate-dyed nanoparticles as reporters. - Clinical Laboratory International 31: 28-29. [I]
Kuningas K. 2007: Kohti fotoluminisenssiin perustuvia homogeenisiä immunomäärityksiä kokoveressä: Upkonvertoivat epäorgaaniset lantanidifosforit uusina reporttereina. - Kliinisen Laboratorioalan julkaisu 5/2007:101 [i]
*von Lode P., *Syrjälä A., *Hagren V., *Kojola H., Soukka T., Lövgren T., *Nurmi J. 2007: Fully automated, homogeneous nucleic acid detection technology based on dry-reagent assay chemistry and time-resolved fluorometry. - Clinical Chemistry 53 (11):2014-7. [C]
Malm J., *Sonesson A., Hellman J., *Bjartell A., *Frohm B,. *Hillarp A. 2007: The pentraxin serum amyloid P component is found in the male genital tract and attached spermatozoa. -International Journal of Andrology ISSN 0105-6263. [C]
*Qin QP., Wittfooth S., Pettersson K. 2007: Measurement and clinical significance of circulating PAPP-A in ACS patients (review). - Clinica Chimica Acta 380:59-67. [C]
Rantanen T., Päkkilä H., Kuningas K., Lövgren T., Soukka T. 2007: Tandem dye with large Stokes' shift in upconversion based homogenous assays. - Clinical Chemistry Laboratory Medicine 45: S203. [D]
Rantanen T., Päkkilä H., Jämsen L., Kuningas K., Ukonaho T., Lövgren T., Soukka T. 2007: Tandem dye acceptor used to enhance upconversion fluorescence resonance energy transfer in homogenous assays. - Analytical Chemistry 79 (16):6312-6318. [C]
Rissanen M., Helo P., Väänänen R-M., Wahlroos V., *Lilja H., *Nurmi M., Pettersson K., *Nurmi J. 2007: Novel homogenous time-resolved fluorometric RT-PCR assays for quantification of PSA and hK2 mRNAs in blood. - Clinical Biochemistry 40:111-118. [C]
*Schallmeiner E., Oksanen E., *Ericsson O., *Spangberg L., Eriksson S., *Stenman UH., Pettersson K., *Landegren U. 2007: Sensitive protein detection via triple-binder proximity ligation assays. - Nature Methods 4 (2):135-137. [C]
*Steuber T., *Vickers A.J., *Serio A.M., Väisänen V., *Haese A., Pettersson K., *Eastham J.A., *Scardino P.T., *Huland H., *Lilja H. 2007: Comparison of free and total forms of serum human kallikrein 2 and prostate-specific antigen for prediction of locally advanced and recurrent prostate cancer. - Clinical Chemistry 53 (2):233-240. [C]
Ukonaho T., Rantanen T., Jämsen L., Kuningas K., Päkkilä H., Lövgren T., Soukka T. 2007: Comparison of infrared-excited up-converting phosphors and europium nanoparticles as labels in a two-site immunoassay. - Analytica Chimica Acta 596:106-115. [C]
Molekulaarisen biotekniikan ja diagnostiikan linja /
Molecular Biotechnology and Diagnostics 2006
Väitöskirjat / Doctoral theses 2006 [sivun alkuun / page top]
Huhtinen P. 2006: Lanthanide Nanoparticles – Preparation and New Applications in Bioaffinity Assays. Turun yliopiston julkaisuja Annales Universitatis Turkuensis, Sarja A 1, osa 352, ss 1-112. [a].
Muu tieteellinen julkaisutoiminta / Other scientific publications 2006
Eriksson S., Pettersson K. 2006: Immunoassay for cardiac troponin I. European patent EP1 473 567B1, Granted 19.07.2006 Bulletin 2006/29. [K]
Eriksson S., Wittfooth S., Pettersson K. 2006: Present and future biochemical markers for detection of acute coronary syndrome. Critical Reviews in Clinical Laboratory Sciences, 43(5-6): 427-495. [C]
*Haaslahti V., *Aalto J., *Oikari T., Soukka T. 2006: Correction method and measurement device for anti-stokes photoluminescence measurement. Patent publication. WO2006125855. [K]
*Hekim C., *Leinonen J., *Närvänen A., *Koistinen H., *Zhu L., *Koivunen E., Väisänen V., *Stenman U-H. 2006: Novel peptide inhibitors of human kallikrein 2 (hK2).J Biol Chem. 281 (18): 12555 -12560. [C]
Hellström J.L., Vehniäinen M., Mustonen M., Lövgren T., Lamminmäki U., Hellmann J. 2006: Unfolding of the immunoglobulin light and heavy chains is required for the enzymatic removal of N-terminal pyroglutamyl residues. Biochimica et Biophysica Acta 1764: 1735-1740. [C]
*Katrukha A., Eriksson S., *Kulmala J. 2006: Troponin I measurement: the concept of a precise immunoassa. As published in CLI .[E]
Kokko L., Jaakohuhta S., *Lindroos P., Soukka T. 2006: Improved Homogeneous Proximity-Based Screening Assay of Potential Inhibitors of 17ß-Hydroxysteroid Dehydrogenases. ASSAY and Drug Development Technologies 4:6, 671-678 [C]
Kuningas K., Ukonaho T., Päkkilä H., Rantanen T., Rosenberg J., Lövgren T., Soukka T. 2006: Upconversion Fluorescence Resonance Energy Transfer in a Homogeneous Immunoassay for Estradiol. Analytical Chemistry 78 (13): 4690- 4696. [C]
von Lode P., *Rainaho J., *Laiho M.K., *Punnonen K., *Peltola O., *Harjola V-P., Pettersson K. 2006: Sensitive and quantitative, 10-min immunofluorometric assay for D-Dimer in whole blood. Thrombosis Research 118, 573-585.[C]
*Lund J., Qin Q-P., Ilva T., *Nikus K., *Eskola M., *Porela P., Kokkala S., *Pulkki K., Pettersson K., *Voipio-Pulkki L-M. 2006: Pregnancy-associated plasma protein A: A biomarker in acute ST-elevation myocardial infarction (STEMI). Annals of Medicine 38: 221-228. [C]
*Pellinen T., *Rytkönen K., Ristiniemi N., *Karp M., Lamminmäki U. 2006: Protein-DNA interaction-based detection of small molecules by employing Renilla luciferase fusion protein: Quantitative and generic measurement of tetracyclines with a Renilla luciferase-tagged Tet repressor protein. Analytical Biochemistry 358: 301-303. [C]
Qin Q-P., Kokkala S., *Lund J., *Tamm N., *Qin X., *Lepäntalo M., Pettersson K. 2006: Immunoassays Developed for Pregnancy-Associated Plasma Protein-A (PAPP-A) in Pregnancy May Not Recognize PAPP-A in Acute Coronary Syndromes. Clinical Chemistry 52 (3) 398-404. [C]
Soukka T., *Korpimäki T., Lamminmäki U., Virta M. 2006: Nanoparticle for bioaffinity assays. Patent publication. US2006148016. [K]
*Steuber T., *Vickers A.J., *Serio A.M., Väisänen V., *Haese A., Pettersson K., *Eastham J.A., *Scardino P.T., *Huland H., *Lilja H. 2007: Comparison of free and total forms of serum human kallikrein 2 and prostate-specific antigen for prediction of locally advanced and recurrent prostate cancer. Clin Chem. 53:2 [C]
*Steuber T., *Vickers A.J., *Haese A., *Becker C., Pettersson K., *Chun F., *Kattan, M., *Eastham, J. *Scardino P., *Huland H., *Lilja H. 2006: Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hk2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum. J. Cancer 118, 1234-1240. [C]
Wittfooth S., Qin Q-P., *Lund J., *Tierala I., *Pulkki K., *Takalo H., Pettersson K. 2006: Immunofluorometric point-of-care assays for the detection of acute coronary syndrome-related noncomplexed pregnancy-associated plasma protein A. Clinical Chemistry 52 (9): 1794-1801. [C]
Väisänen V., Pettersson K., *Alanen K., *Viitanen T., *Nurmi M. 2006: Free and total human grandular kallikrein 2 in patients with prostate cancer. Urology. 68, 219-225. [C]
Väisänen V., Peltola M.T., *Lilja H., *Nurmi M., Pettersson K. 2006: Intact Free Prostate-Specific Antigen and Free and Total Human Glandular Kallikrein 2. Elimination of Assay Interference by Enzymatic Digestion of Antibodies to
F(ab´)2 Fragments. Analytical Chemistry;78(22) : 7809-7815. [C]
Välimaa L., Laurikainen K. 2006: Comparison study of streptavidin-coated microtitration plates. Journal of Immunological Methods 308: 203-215. [C]
Ylikotila J., Hellström J.L., Eriksson S., Vehniäinen M., Välimaa L., *Takalo H., *Bereznikova A., Pettersson K. 2006: Utilization of recombinant Fab fragments in a c TnI immunoassay conducted in spot wells. Clinical Biochemistry. 39, 843-850. [C]
Molekulaarisen biotekniikan ja diagnostiikan linja /
Molecular Biotechnology and Diagnostics 2005
Väitöskirjat / Doctoral theses 2005 [sivun alkuun / page top]
Eriksson, S. 2005: Novel Immunoassays for cardiac troponin I: Reducing negative interference from troponin autoantibodies. Annales Universitatis Turkuensis AI 332, 80 p.
Santala, V. 2005: Implications of tight binding: Capture of autobody fragments and recovery of high-affinity binders in phage display. Annales Universitatis Turkuensis AI 336, 72 p.
von Lode, P. 2005: Novel quantitative immunoassays for high-performance point-of-care-testing. Annales Universitatis Turkuensis AI 330, 106 p.
Muu tieteellinen julkaisutoiminta / Other scientific publications 2005
Bienenmann-Ploum, M., Korpimäki T., Haasnoot W., Kohen F. 2004: Comparison of multi-sulfonamide biosensor immunoassays. Analytica Chimica Acta 529(1-2): 115-122. [C]
Brockmann, E.-C., *Cooper, M., *Strömsten, N., Vehniäinen, M., *Saviranta, P. 2005: Selecting for antibody scFv fragments with improved stability using phage display with denaturation under reducing conditions. Journal of Immunological Methods 296(1-2):159-170. [C]
Brockmann, E.-C., Lamminmäki, U., *Saviranta, P. 2005: Engineering dihydropteroate synthase (DHPS) for efficient expression on M13 phage. Biochimica et Biophysica Acta 1724(1-2):146-154. [C]
Eriksson, S., Pettersson, K. 2004: The interfering component in cardiac troponin I immunoassays [Letter]. Clin Chem 50(6): 1101-1102. [C]
Eriksson, S., Halenius, H., *Pulkki K., Hellman, J., Pettersson, K. 2005: Negative interference in cardiac troponin I immunoassays by circulating troponin autoantibodies. Clinical Chemistry 51(5): 839-847. [C]
Eriksson, S., Ilva, T., *Becker, C., Lund, J., Porela, P., *Pulkki, K., *Voipio-Pulkki, L-M., Pettersson, K. 2005: Comparison of cardiac troponin I immunoassays variably affected by circulating autoantibodies. Clinical Chemistry 51(5): 848-855. [C]
Eriksson, S., Hellman, J., Pettersson, K. 2005: Autoantibodies against cardiac troponins [Letter]. New England Journal of Medicine 352(1): 98-100. [C]
Eriksson, S., Pettersson, K. 2005: Beliefs in cardiac troponin testing [Letter]. Clinical Chemistry 51(9): 1755-1756. [C]
Eriksson, S., Pettersson, K. 2005: Troponin som biokemisk markör vid diagnostic av hjärtinfarkt. Klinisk Biokemi i Norden 2005(4): 24-31. [I]
*Haaslahti, V., *Aalto, J., *Oikari, T., Soukka, T. 2005: Virheenkorjausmenetelmä anti-Stokes fotoluminesenssin mittauksessa ja mittauslaite. Patenttijulkaisu FI20050551. [K]
*Haasnoot W., *Bienenmann-Ploum, M., Lamminmäki U., *Swanenburg M., *van Rhijn, H. 2005: Application of a multi-sulfonamide biosensor immunoassay for the detection of sulfadiazine and sulfamethoxazole residues in broiler serum and its use as a predictor of the levels in edible tissue. Analytica Chimica Acta 552(1-2): 87-95. [C]
*Haese, A., Väisänen, V., *Lilja, H., *Kattan, M.W., *Rittenhouse, H.G., Pettersson, K., *Chan, D.W., *Huland, H., *Sokoll L.J., *Partin A.W. 2005: Comparison of predictive accuracy for pathologically organ confined clinical stage T1c prostate cancer using human glandular kallikrein 2 and prostate specific antigen combined with clinical stage and Gleason grade. Journal of Urology 173(3): 752-756. [C]
Hagrén, V., *Connolly, L., *Elliott, C.T., Lövgren, T., Tuomola, M. 2005: Rapid screening method for halofuginone residues in poultry eggs and liver using time-resolved fluorometry combined with the all-in-one dry chemistry assay concept. Analytica Chimica Acta 529(1-2): 21-25. [C]
Hagrén, V., Peippo, P., Lövgren, T. 2005: Detecting and controlling veterinary drug residues in poultry. In: Mead, G.C. (ed.): Food safety control in the poultry industry. Cambridge: Woodhead Publishing Limited, pp. 44-82. [D]
Ilva, T., Eriksson, S., Lund, J., Porela, P., *Mustonen, H., Pettersson, K., *Pulkki, K., *Voipio-Pulkki, L-M. 2005: Improved early risk stratification and diagnosis of myocardial infarction, using a novel troponin I assay concept. European Journal of Clinical Investigation 35(2): 112-116. [C]
Ivaska, K.K., Pettersson, K., *Nenonen, A., *Uusi-Rasi, K., *Heinonen, A., *Kannus, P., Väänänen, H.K. 2005: Urinary osteocalcin is a useful marker for monitoring the effect of alendronate therapy. Clinical Chemistry 51(12): 2362-2365. [C]
Ivaska, K.K., Käkönen, S.-M., *Gerdhem, P., *Obrant, K.J., Pettersson, K., Väänänen, H.K. 2005: Urinary osteocalcin as a marker of bone metabolism. Clinical Chemistry 51(3): 618-628. [C]
Kiviniemi, M., Nurmi, J., Lövgren, T., Ilonen, J. 2005: Locked nucleic acid (LNA) probes in high-throughput genetic analysis: Application to an assay for type 1 diabetes-related HLA-DQB1 alleles. Clinical Biochemistry 38(11): 1015-1022. [C]
Kokko, L., Johansson, N., Lövgren, T., Soukka, T. 2005: Enzyme inhibitor screening using a homogenous proximity-based immunoassay for estradiol. Journal of Biomolecular Screening 10: 348-354. [C]
Kuningas, K., Rantanen, T., Karhunen, U., Lövgren, T., Soukka, T. 2005: Simultaneous use of time-resolved fluorescence and anti-Stokes photoluminescence in a bioaffinity assay. Analytical Chemistry 77(9): 2826-2834. [C]
Kuningas, K., Rantanen, T., Lövgren, T., Soukka, T. 2005: Enhanced photoluminescence of up-converting phosphors in a solid phase bioaffinity assay. Analytica Chimica Acta 543(1-2): 130-136. [C]
Kuningas, K., Rantanen, T., Ukonaho, T., Lövgren, T., Soukka, T. 2005: Homogenous assay technology based on up-converting phosphors. Analytical Chemistry 77(22): 7348-7355. [C]
*Kupari, M., Eriksson, S., *Turto, H., *Lommi, J., Pettersson, K. 2005: Leakage of cardiac troponin I in aortic valve stenosis. Journal of Internal Medicine 258(3): 231-237. [C]
Mäkivuokko H., Nurmi J., Nurminen, P., Stowell J., Rautonen N. 2005: In vitro effects on polydextrose by colonic bacteria and caco-2 cell cyclooxygenase gene expression. Nutrition and Cancer 52(1): 94-104. [C]
Nurmi, J., *Puolakkainen, P.A., *Rautonen, N.E. 2005: Bifidobacterium lactis sp. 420 Up-regulates cyclooxygenase (Cox)-1 and down-regulates cox-2 gene expression in a caco-2 cell culture model. Nutrition and Cancer 51(1): 83-92. [C]
Nurmi J.T., *Puolakkainen P.A., *Rautonen N.E. 2005: Intron 1 retaining cyclooxygenase 1 splice variant is induced by osmotic stress in human intestinal epithelial cells. Prostaglandins, Leukotrienes and Essential Fatty Acids 73(5): 343-350. [C]
*Obrant, K.J., Ivaska, K.K., *Gerdhem, P., Alatalo, S.L. Pettersson, K., Väänänen H.K. 2005: Biochemical markers of bone turnover are influenced by recently sustained fracture. Bone 36(5): 786-792. [C]
*Parra, M.D., Väisänen, V., *Ceron, J.J. 2005: Development of a time-resolved fluorometry based immunoassay for the determination of canine haptoglobin in various body fluids. Veterinary Research 36(1): 117-129. [C]
Peippo, P., Lövgren, T., Tuomola, M. 2005: Rapid screening of narasin residues in poultry plasma by time-resolved fluoroimmunoassay. Analytica Chimica Acta 529:27-31. [C]
Salminen, S., Nurmi J., Guiemonde, M. 2005: The genomics of probiotic intestinal microorganisms. Genome Biology 6:225. [F]
Soukka, T., Kuningas, K., Rantanen, T., Haaslahti, V., Lövgren, T. 2005: Photochemical characterization of up-converting inorganic lanthanide phosphors as potential labels. Journal of Fluorescence 15(4): 513-528. [C]
Soukka, T., *Oikari, T., *Haaslahti, V. 2005: Homogeeninen luminesenssibiomääritys. Patenttijulkaisu FI20051204. [K]
*Steuber, T., Niemelä, P., *Haese, A., Pettersson, K., *Erbersdobler, A., *Felix Chun, K.H., *Graefen, M., *Kattan, M.W., *Huland, H., *Lilja, H. 2005: Association of free-prostate specific antigen subfractions and human glandular kallikrein 2 with volume of benign and malignant prostatic tissue. Prostate 63(1): 13-18. [C]
Valanne, A., Lindroos, H., Lövgren, T., Soukka, T. 2005: A novel homogeneous assay format utilising proximity dependent fluorescence energy transfer between particulate labels. Analytica Chimica Acta 539: 251-256. [C]
Valanne, A., Huopalahti, S., Soukka, T., *Vainionpää, R., Lövgren, T., Härmä, H. 2005: A sensitive adenovirus immunoassay as a model for using nanoparticle label technology in virus diagnostics. Journal of Clinical Virology 33: 217-223. [C]
Valanne, A., Huopalahti S., *Vainionpää, R., Lövgren, T., Härmä, H. 2005: Rapid and sensitive HbsAg immunoassay based on fluorescent nanoparticle labels and time-resolved detection. Journal of Virological Methods 129: 83-90. [C]
*van Gils, M.P., *Stenman, U.H., *Schalken, J.A., *Schroder, F.H., *Luider, T.M., *Lilja, H., *Bjartell, A., *Hamdy, F.C., Pettersson, K.S., *Bischoff, R., *Takalo, H., *Nilsson, O., *Mulders, P.F., *Bangma, C.H. 2005: Innovations in serum and urine markers in prostate cancer current European research in the P-Mark project. European Urology 48(6): 1031-1041. [F]
Vesterlund, S., Paltta, J., Karp, M., Ouwehand, A.C. 2005: Measurement of bacterial adhesion – in vitro evaluation of different methods. Journal of Microbiological Methods 60: 225-233. [C]
von Lode, P. 2005: Point-of-care immunotesting: Approaching the analytical performance of central laboratory methods. Clinical Biochemistry 38(7): 591-606. [F]
Wikman, T., Antonen, K., Korpimäki, T., Lövgren, T., Nurmi, J. 2005: A rapid nucleic acid detection method for specific bacteria: The case of Listeria monocytogenes. In: van Amerongen, A., Barug, D. ja Lauwaars, M. (eds.): Rapid methods for biological and chemical contaminants in food and feed. Wageningen Academic Publishers, pp. 127-134. [D]
Ylikotila, J., Välimaa, L., Vehniäinen, M., *Takalo, H., Lövgren, T., Pettersson, K. 2005: A sensitive TSH assay in spot-coated microwells utilizing recombinant antibody fragments. Journal of Immunological Methods 306(1-2): 104-114. [C]
*Åkesson, K., Käkönen, S.-M., *Josefsson, P.O., *Karlsson, M.K., *Obrant, K.J., Pettersson, K. 2005: Fracture-induced changes in bone turnover: a potential confounder in the use of biochemical markers in osteoporosis. Journal of Bone and Mineral Metabolism 23:30-35. [C]
Qin, Q.-P., Kokkala, S., Lund, J., *Tamm, N., *Voipio-Pulkki, L.-M., Pettersson, K. 2005: Molecular distinction of circulating pregnancy-associated plasma protein A in myocardial infarction and pregnancy. Clinical Chemistry 51(1): 75-83. [C]
Qin, Q.-P., Pettersson K. 2005: Improved method for diagnosing acute coronary syndrome. Patenttijulkaisu PCT/FI2005000036. [K]