Biokemian linjan tieteelliset julkaisut /
Biochemistry publications
2011 2010 2009 2008 2007 2006 2005 2004 2003 2002
Biokemian linja / Biochemistry 2011
Väitöskirjat / Doctoral theses 2011 [sivun alkuun / page top]
Juha Rantala (2011) A cell spot microarray method for high-throughput biology. Annales Universitatis Turkuensis D969.
Joonas Jämsén (2011) Functional studies on bacterial nucleotide-regulated inorganic pyrophosphatases. Annales Universitatis Turkuensis A I 421
Heidi Tuominen (2011) The structural basis for inorganic pyrophosphatase catalysis and regulation. Annales Universitatis Turkuensis A I 417
Muu tieteellinen julkaisutoiminta / Other scientific publications 2011
[sivun alkuun / page top]
Siitonen, V., Claesson, M., Patrikainen, P., Aromaa, M., Mäntsälä, P., Schneider, G., and Metsä-Ketelä, M (2011) Identification of late-stage glycosylation steps on the biosynthetic pathway of the anthracycline nogalamycin. ChemBioChem 13 (1): 120-128.
Pramod Kumar Rompikuntal, Bernard Thay, Muhammad Khanzeb Khan, Jonna Alanko, Anna-Maija Penttinen, Sirkka Asikainen, Sun Nyunt Wai, and Jan Oscarsson (2011) Perinuclear localization of internalized Outer Membrane Vesicles carrying active Cytolethal Distending Toxin (CDT) from Aggregatibacter actinomycetemcomitans. Infect. Immun. in press.
Hellman M., Tossavainen H., Rappu P., Heino J., Permi P. (2011) Characterization of Intrinsically Disordered Prostate Associated Gene (PAGE5) at Single Residue Resolution by NMR Spectroscopy. PLoS One 6(11):e26633
Lahti M., Bligt E., Niskanen H., Parkash V., Brandt A.M., Jokinen J., Patrikainen P., Käpylä J., Heino J., Salminen T.A. (2011) Structure of Collagen Receptor Integrin α1I Domain Carrying the Activating Mutation E317A. J. Biol. Chem. 286:xx-xx.
Chouhan B., Denesyuk A., Heino J., Johnson M.S., Denessiouk K. (2011) Conservation of the human integrin-type Beta-propeller domain in bacteria. PLoS One 6(10):e25069
Koivunen J.T., Nissinen L., Käpylä J., Jokinen J., Pihlavisto M., Marjamäki A., Heino J., Huuskonen J., Pentikäinen O.T. (2011) Fluorescent small molecule probe to modulate and explore α2β1 integrin function. J. Am. Chem. Soc. 133(37):14558-61.
Ivaska J, Heino J. (2011) Cooperation between integrins and growth factor receptors in signaling and endocytosis. Annu. Rev. Cell Dev. Biol. 27:291-320.
Larjava H, Koivisto L, Häkkinen L, Heino J. (2011) Epithelial integrins with special reference to oral epithelia. J. Dent. Res. 2011 90(12):1367-76.
Larjava H, Wiebe C, Gallant-Behm C, Hart DA, Heino J, Häkkinen L. (2011) Exploring scarless healing of oral soft tissues. J. Can. Dent .Assoc. 77:b18.
Luoto HH, Belogurov GA, Baykov AA, Lahti R, Malinen AM. (2011) Na+-translocating membrane pyrophosphatases are widespread in the microbial world and evolutionarily precede H+-translocating pyrophosphatases. J Biol Chem 286(24):21633-21642.
Veit G., Zwolanek D., Eckes B., Niland S., Käpylä J., Zweers M.C., Ishada-Yamamoto A., Krieg T., Heino J., Eble J.A., Koch M. (2011).Collagen XXIII, Novel Ligand for Integrin {alpha}2{beta}1 in the Epidermis. J. Biol. Chem. 286(31):27804-27813
Kallio, P., Patrikainen, P., Suomela, J-P., Mäntsälä, P., Metsä-Ketelä, M. and Niemi, J. (2011) Flavoprotein Hydroxylase PgaE Catalyses Two Consecutive Oxygen-Dependent Tailoring Reactions in Angucycline Biosynthesis. Biochemistry, 50(24):5535-5543.
Tarry M., Jääskeläinen M., Paino A., Tuominen H., Ihalin R., Högbom M. (2011) The extra-membranous domains of the competence protein HofQ show DNA-binding, flexibility and a shared fold with type-I KH-domains. J Mol Biol; 409: 642-653.
Paino A., Tuominen H., Jääskeläinen M., Alanko J., Nuutila J., Asikainen S., Pelliniemi L.J., Pöllänen M.T., Chen C., Ihalin R. (2011) Trimeric Form of Intracellular ATP Synthase Subunit β of Aggregatibacter actinomycetemcomitans Binds Human Interleukin-1β. PLoS ONE 6(4): e18929.
Kuokkanen, E., Stensland, H. M. F. R., Smith, W., Buvang, E., Nguyen, L., Nilssen, Ø & Heikinheimo, P. (2011). Molecular and Cellular characterisation of novel α-mannosidosis mutations. Human Molecular Genetics, in press
Bernon, C., Carre, Y., Kuokkanen, E., Slomianny, M.C., Mir, A.M.,Krzewinski, F., Cacan, R., Heikinheimo, P., Morelle, W., Michalski, J.C.Foulquier, F. and Duvet, S. (2011) Over expression of Man2C1 leads to protein underglycosylation and up-regulation of ERAD pathway. Glycobiology, 21, 363-375
Rappu P., Nylund C., Ristiniemi N., Kulpakko J., Vihinen P., Hernberg M., Mirtti T., Alanen K., Kallajoki M., Vuoristo M. S., Pyrhönen S., Heino J. (2011) Detection of melanoma-derived cancer-testis antigen CT16 in patient sera by a novel immunoassay. Int. J. Cancer 128(10): 2382-2392
Jämsen, J., Tuominen, H., Baykov A. and Lahti R. (2011) Mutational analysis of residues in the regulatory CBS domains of Moorella thermoacetica pyrophosphatase corresponding to disease-related residues of human proteins. Biochem. J. 433: 497-504.
Biokemian linja / Biochemistry 2010
Väitöskirjat / Doctoral theses 2010 [sivun alkuun / page top]
Jokinen, J. (2010) Conformational Regulation of alpha2beta1 Integrin in Ligand Binding.
Annales Universitatis Turkuensis A I 407, 82 [115] p.
Muu tieteellinen julkaisutoiminta / Other scientific publications 2010
Belogurov, G. A.; Malinen, A; Vainonen, L. & Turtola, M. 2010: Tree of life revisited: a transcriptional view. In: Proceedings of the 69th Harden Conference. RNAP2010: Structure, function and evolution of RNA polymerases. p. 31 [A4]
Belogurov G. A., Sevostyanova A., Svetlov V., Artsimovitch I. (2010). Functional regions of the N-terminal domain of the antiterminator RfaH. Mol. Microbiol. 76 (2): 286-301
Grocholski, T., Koskiniemi, H., Lindqvist, Y., Mäntsälä, P., Niemi, J. and Schneider, G. (2010) Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism. Biochemistry 49(5): 934-944.
Heino, J. & Vuento*, M. 2010: Biokemian ja solubiologian perusteet. Porvoo: WSOY, 352 s. [d5]
Ivaska, J. and J. Heino. (2010) Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes. Cell Tissue Res. (1)339:111-120.
Jokinen, J., D. J. White, M. Salmela, M. Huhtala, J. Kapyla, K. Sipila, J. S. Puranen, L. Nissinen, P. Kankaanpaa, V. Marjomaki, T. Hyypia, M. S. Johnson, and J. Heino. (2010) Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1. EMBO J. (1)29:196-208.
Jämsen J, Baykov AA, Lahti R. (2010) Nucleotide- and substrate-induced conformational transitions in the CBS domain-containing pyrophosphatase of Moorella thermoacetica. Biochemistry 49(5):1005-13.
Liljeblad, A., Kallio, P., Vainio, M., Niemi, J. and Kanerva, L. T. (2010) Formation and hydrolysis of amide bonds by lipase A from Candida antarctica; exceptional features. Org. Biomol. Chem. 8: 886-895.
Nissinen, L., O. T. Pentikainen, A. Jouppila, J. Kapyla, M. Ojala, J. Nieminen, A. Lipsanen, H. Lappalainen, B. Eckes, M. S. Johnson, R. Lassila, A. Marjamaki, and J. Heino. (2010) A small-molecule inhibitor of integrin alpha2 beta1 introduces a new strategy for antithrombotic therapy. Thromb. Haemost. (2)103:387-397.
Nuutila, J. (2010) The novel applications of the quantitative analysis of neutrophil cell surface FcgammaRI (CD64) to the diagnosis of infectious and inflammatory diseases. Current Opinion in Infectious Diseases 23(3): 268-74.
Tuominen H, Salminen A, Oksanen E, Jämsen J, Heikkilä O, Lehtiö L, Magretova NN, Goldman A, Baykov AA, Lahti R. (2010). Crystal structures of the CBS and DRTGG domains of the regulatory region of Clostridiumperfringens pyrophosphatase complexed with the inhibitor, AMP, and activator, diadenosine tetraphosphate. J Mol Biol. 398(3):400-413.
Zeltz*, C.; Brézillon*, S.; Käpylä, J.; Eble*, J.A.; Bobichon*, H.; Terryn*, C.; Perreau*, C.; Franz*, C.M.; Heino, J.; Maquart*, F.X. & Wegrowski*, Y. 2010: Lumican inhibits cell migration through alpha2beta1 integrin. - Experimental Cell Research 316(17): 2922-2931. [A1]
Biokemian linja / Biochemistry 2009
Väitöskirjat / Doctoral theses 2009 [sivun alkuun / page top]
Malinen, A. 2009: Discovery and characterization of Na+-transporting pyrophosphatases. Annales Universitatis Turkuensis AI 396, 67 [35] p.
Muu tieteellinen julkaisutoiminta / Other scientific publications 2009
Heino, J. 2009: a2 integrin. UCSD-Nature Signaling Gateway Molecule Page. Peer-reviewed review article published in www.signaling-gateway.org by Nature Publishing company. [F]
Heino, J., Huhtala, M., Käpylä, J. & Johnson, M.S. 2009: Evolution of collagen-based adhesion systems. "Darwin 2009" issue. - International Journal of Biochemistry and Cell Biology 41 (2): 341-348. [F]
Heino, J. & Käpylä, J. 2009: Cellular receptors of extracellular matrix molecules. - Current Pharmaceutical Design 15 (12): 1309-1317. [F]
Jalava-Karvinen, P., Hohenthal, U., Laitinen, I., Kotilainen, P., Rajamäki, A., Nikoskelainen, J., Lilius, E-M., Nuutila, J. 2009: Simultaneous quantitative analysis of Fc gamma RI (CD64) and CR1 (CD35) on neutrophils in distinguishing between bacterial infections, viral infections, and inflammatory diseases. - Clinical Immunology 133(3): 314-23. [C]
Johnson*, M.S., Lu*, N., Denessiouk*, K., Heino, J. & Gullberg*, D. 2009: Integrins during evolution: evolutionary trees and model organisms. - Biochemical Biophysical Acta - Biomembranes 1788 (4): 779-789. [F]
Kilpi, M., Atosuo, J., Lilius, E-M. 2009: Bacteriolytic activity of the alternative pathway of complement differs kinetically from the classical pathway.- Developmental and Comparative Immunology 33(10): 1102-10. [C]
Koskiniemi*, H., Grocholski, T., Schneider*, G., and Niemi, J. 2009: Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway - Acta Cryst. F65: 256-259. [C]
Käpylä, J., Airenne*, T.T., Johnson*, M.S. & Heino J. 2009: Conformational modifications and receptor clustering in the regulation of integrin function. In: Bank, I. (ed.): Effector memory T cell subsets in the extralymphatic tissue - interactions with the extracellular matrix influencing functions. Research Signpost, Kerala, India. pp. 29-42. [D]
Lindqvist*, Y., Koskiniemi*, H., Jansson*, A., Sandalova*, T., Schnell*, R., Liu, Z., Mäntsälä, P., Niemi, J., and Schneider*, G. 2009: Structural Basis for Substrate Recognition and Specificity in Aklavinone-11-Hydroxylase from Rhodomycin Biosynthesis - J. Mol. Biol. 393: 966–977. [C]
Nuutila, J., Jalava-Karvinen, P., Hohenthal, U., Laitinen, I., Kotilainen, P., Rajamäki, A., Nikoskelainen, J., Lilius, E-M. 2009: Comparison of degranulation of easily mobilizable intracellular granules by human phagocytes in healthy subjects and patients with infectious diseases - Human Immunology 70(10): 813-9. [C]
Nuutila, J., Jalava-Karvinen, P., Hohenthal, U., Laitinen, I., Kotilainen, P., Rajamäki, A., Nikoskelainen, J., Lilius, E-M. 2009: CRP/CD11b ratio: a novel parameter for detecting gram-positive sepsis - Human Immunology 70(4): 237-43. [C]
Biokemian linja / Biochemistry 2008
Väitöskirjat / Doctoral theses 2008 [sivun alkuun / page top]
Kallio, P. 2008: Type II Aromatic Polyketide Biosynthetic Tailoring Enzymes: Diversity and Adaptation In Streptomyces Secondary Metabolism. Annales Universitatis Turkuensis A I 386, 116 p.
Muu tieteellinen julkaisutoiminta / Other scientific publications 2008
*Abair, T.D., *Sundaramoorthy, M., *Chen, D., Heino, J., Ivaska, J., *Hudson, B.G., *Pozzi A., *Zent R. 2008: The interplay between integrins ?1?1 and ?2?1 in renal cell tubulogenesis. ? Exp Cell Res 314: 3593-3604. [C]
*Bergman, L., *Rosenholm, J., Öst, A-B., *Duchanoy, A., Kankaanpää, P., Heino, J. and *Linden, M. 2008: On the Complexity of Electrostatic Suspension Stabilization of Functionalized Silica Nanoparticles for Biotargeting and Imaging Applications. ? Journal of Nanomaterials Article ID 712514. [C]
Kallio, P., Liu, Z., Mäntsälä, P., Niemi, J., Metsä-Ketelä, M. 2008: A Nested Gene in Streptomyces Bacteria Encodes a Protein Involved in Quaternary Complex Formation. ? J. Mol. Biol. 375: 1212-1221 [C]
Kallio, P., Liu, Z., Mäntsälä, P., Niemi, J. and Metsä-Ketelä, M. 2008: Sequential Action of Two Flavoenzymes, PgaE and PgaM, in Angucycline Biosynthesis: Chemoenzymatic Synthesis of Gaudimycin C. ? Chemistry & Biology 15:157-166. [C]
Kankaanpää, P., Pahajoki, K., *Marjomäki, V., *White, D.J., Heino, J. 2008: BioImageXD - Free Microscopy Image Processing Software. Microsc Microanal. 14 Suppl 2:724-725. [D]
Kankaanpää, P., Pahajoki, K., *Paavolainen, L., *Marjomäki, V., *White, D., Heino, J. 2008: BioImageXD – a Large Software Development Project for Bioimaging Purposes. In: Tuominen, A., Kantola, J., Suominen, A., Hyrynsalmi, S. (Eds.): Proceedings of NEXT 2008, The Fifth International New Exploratory Technologies Conference. TUCS General Publication No 50, August 2008, pp. 13-18 [D]
*Karched, M., Ihalin, R., *Eneslätt, K., *Zhong, D., *Oscarsson, J., *Wai, S.N., *Chen, C., *Asikainen, S.E. 2008: Vesicle-independent extracellular release of a proinlammatory outer membrane lipoprotein in free-soluble form. – BMC Microbiology 8 (18). [C]
*Karjalainen, M., *Kakkonen, E., *Upla, P., *Paloranta, H., Kankaanpää, P., *Liberali, P., *Renkema, G. H., *Hyypiä, T., Heino, J., *Marjomäki, V. 2008: A Raft-derived, Pak1-regulated Entry Participates in alpha2beta1 Integrin-dependent Sorting to Caveosomes. ? Mol Biol Cell. 19(7):2857-69. [C]
Malinen, A., *Baykov, A. A. & Lahti, R. 2008: Mutual effects of cationic ligands and substrate on activity of the Na+-transporting pyrophosphatase of Methanosarcina mazei. – Biochemistry 47:13447-13454. [C]
*Marjomäki, V., *Huhtala, M., *Karjalainen, M., Hyypiä, T., Heino, J. 2008: Functions of integrin ?2?1, a collagen receptor, in the internalization of echovirus 1. In: Structure based studies of viral replication. Eds. R.H. Cheng, T. Miyamura. World Scientific, Singapore. pp. 63-75. [D]
*Metsä-Ketelä, M., Niemi, J., Mäntsälä, P., and *Schneider, G. 2008: Anthracycline Biosynthesis: Genes, Enzymes and Mechanisms in Top Curr Chem 282, Springer-Verlag Berlin/Heidelberg. [F]
Niemi, J., *Metsä-Ketelä, M., *Schneider, G., and Mäntsälä, P. 2008: Biosynthetic Anthracycline Variants in Top Curr Chem 282, Springer-Verlag Berlin/Heidelberg. [F]
Nuutila, J. 2008: Clinical exploitations of quantitative analysis of complement/Fc?-receptors on human phagocytes. Teoksessa New Research on Innate Immunity, Nova Science Publishers, Inc. Chapter 8. ISBN: 978-1-60456-549-2 [D]
Nuutila, J., *Hohenthal, U., Laitinen I., *Kotilainen, P., *Rajamäki, A., *Nikoskelainen, J. & Lilius, E.-M. 2008: A novel method for distinguishing between dsDNA and ssRNA virus infections. ? Journal of Clinical Virology 43: 49-55 [C]
Oja, T., Palmu, K., Lehmussola, H., Leppäranta, O., Hännikäinen, K., Niemi, J., Mäntsälä, P. & Metsä-Ketelä M. 2008: Characterization of the Alnumycin Gene Cluster Reveals Unusual Gene Products for Pyran Ring Formation and Dioxan Biosynthesis. – Chemistry & Biology 15:1046-57. [C]
Pahajoki, K., Kankaanpää, P., Heino, J. 2008: BioImageXD software in batch analysis of integrin interactions. Microsc Microanal. 14 Suppl 2:596-597. [D]
Soilu-Hänninen, M., Laaksonen, M., Laitinen, I., Erälinna, J.P., Lilius, E-M., Mononen, I. 2008: A longitudinal study of serum 25-hydroxyvitamin D and intact PTH levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis. ? J Neurol Neurosurg Psychiatry. 79: 152-157. [C]
Tammenkoski, M., Koivula, K., *Cusanelli, E., *Zollo, M., *Steegborn, C., *Baykov, A.A. & Lahti, R. 2008: Human metastasis regulator protein h-prune is a short-chain exopolyphosphatase. – Biochemistry 47: 9707-9713. [C]
Tulla, M., *Helenius, J., Jokinen, J., *Taubenberger, A., *Muller, D., Heino, J. 2008: TPA primes ?2?1 integrins for cell adhesion. ? FEBS letters 582: 3520-3524. [C]
Tulla, M., Lahti, M., *Puranen, J.S., *Brandt, A-M., *Burcza, A., Käpylä, J., *Domogatskaya, A., *Salminen, T.A., *Tryggvason, K., *Johnson, M.S., Heino, J. 2008: Effects of conformational activation of integrin a1I and a2I domains on selective recognition of laminin and collagen subtypes. ? Exp Cell Res 314: 1734-1743. [C]
*Upla, P., *Marjomäki, V., Nissinen, L., Nylund, C., Waris, M., Hyypiä, T., Heino, J. 2008: Calpain 1 and 2 are required for the RNA replication of echovirus 1. ? J Virol 82: 1581-1590. [C]
Vuoriluoto, K., Jokinen, J., Kallio, K., Salmivirta, M., Heino J., Ivaska, J. 2008: Syndecan-1 supports integrin alpha2beta1-mediated adhesion to collagen. ? Exp Cell Res. 314: 3369-3381. [C]
Biokemian linja / Biochemistry 2007
Väitöskirjat / Doctoral theses 2007 [sivun alkuun / page top]
Kauko, A. 2007: Iron and Oxidative Stress: Structural Studies on Dps-like Peroxide Resistance Protein (Dpr) from Streptococcus suis. Annales Universitatis Turkuensis A I 360, 109 p.
Lehtinen, J. 2007: Improvements in the Assessment of Bacterial Viability and Killing. Annales Universitatis Turkuensis A I 372, 116 p.
Tammenkoski, M. 2007: One Bond - Many Enzymes: Functional Studies of Three Enzymes Hydrolyzing the Phosphoanhydride Bond. Annales Universitatis Turkuensis A I 363, 106 p.
Muu tieteellinen julkaisutoiminta / Other scientific publications 2007
Airas, K. R. 2007: Magnesium dependence of the measured equilibrium constants of aminoacyl-tRNA synthetases. - Biophysical Chemistry 131: 29-35. [C]
Alexeev, I., *Sultana, A., Mäntsälä, P., Niemi, J. and *Schneider G. 2007: AknOx from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site. - Proceedings of the National Academy of Sciences 104(15):6170-5 [C]
Connors, W.L., Jokinen, J., *White, D.J., *Puranen, J.S., Kankaanpää, P., *Upla, P., Tulla, M., *Johnson, M.S., Heino, J. 2007: Two synergistic activation mechanisms of alpha2beta1 integrin-mediated collagen binding. - J Biol Chem. 282: 14675-83. [C]
*Fabrichniy I. P., *Lehtiö L., Tammenkoski M., *Zyryanov A.B., *Oksanen E., *Baykov A.A., Lahti R. & *Goldman A. 2007: A trimetal site and substrate distortion in a family II inorganic pyrophosphatase. – J. Biol. Chem. 282: 1422-1431. [C]
Heino J. 2007: The collagen family members as cell adhesion proteins. - BioEssays 29: 1001-1010. [F]
Heino J., Vuento M. 2007: Biokemian ja solubiologian perusteet. Porvoo: WSOY, 349 s. [h]
Jämsen, J., Tuominen, H., Salminen, A., Belogurov, G., *Magretova, N., *Baykov, A., & Lahti, R. 2007: A CBS domain-containing pyrophosphatase of Moorella thermoacetica is regulated by adenine nucleotides. - Biochem J 408: 327-333. [C]
Kankaanpää, P. 2007: BioImageXD User Manual. http://www.bioimagexd.net: 49 sivua. [J]
*Koskiniemi, H., Metsä-Ketelä, M., *Dobritzsch, D., Kallio, P., Korhonen, H., Mäntsälä, P., *Schneider, G., Niemi, J. 2007: Crystal Structures of Two Aromatic Hydroxylases Involved in the Early Tailoring Steps of Angucycline Biosynthesis. - Journal of Molecular Biology 372: 633-48 [C]
Kuokkanen, E., *Smith, W., Mäkinen, M., Tuominen, H., *Puhka, M., *Jokitalo, E., *Duvet, S., *Berg, T., & Heikinheimo, P. 2007: Characterization and subcellular localization of human neutral class II alpha-mannosidase cytosolic enzymes/free oligosaccharides/glycosidehydrolase family 38/M2C1/N-glycosylation. - Glycobiology 17: 1084-1093. [C]
Käpylä, J., *Pentikäinen, O.T., *Nyrönen, T., *Nissinen, L., Lassander, S., Jokinen, J., Lahti, M., *Marjamäki, A., *Johnson, M.S., and Heino, J. 2007: Small Molecule Designed to Target Metal Binding Site in the a2I Domain Inhibits Integrin Function. J. Med. Chem. 50: 2742-2746. [C]
Malinen, A.M., Belogurov, G.A., *Baykov, A.A. & Lahti, R. 2007: Na+-pyrophosphatase: A novel primary sodium pump. – Biochemistry 46: 8872-8878. [C]
Nuutila J., Hohenthal U., Laitinen I., Kotilainen P., Rajamäki A., Nikoskelainen J. & Lilius E.-M. 2007: Simultaneous quantitative analysis of Fc?RI (CD64) expression on neutrophils and monocytes: A new, improved way to detect infections. - J Immunol Methods 328/1-2: 189-200 [C]
Nuutila, J. & Lilius, E.-M. 2007: Distinction between bacterial and viral infections. - Current Opinion in Infectious Diseases 20(3): 304-310 [F]
*Oksanen, E., *Ahonen, A.-K., Tuominen, H., Tuominen, V., Lahti, R., *Goldman, A. & *Heikinheimo, P. 2007: A complete structural description of the catalytic cycle of yeast pyrophosphatase. – Biochemistry 46: 1228 -1239. [C]
Palmu, K., *Ishida, K., Mäntsälä, P., *Hertweck, C. and Metsä-Ketelä, M. 2007: Artificial Reconstruction of Two Cryptic Angucycline Antibiotic Biosynthetic Pathways. - ChemBioChem 8:1577-1584 [C]
*Rinne, J., *Albarran, B., *Jylhävä, J., *Ihalainen, T. O., Kankaanpää, P., *Hytönen, V. P., *Stayton, P.S., *Kulomaa, M. S., *Vihinen-Ranta, M. 2007: Internalization of novel non-viral vector TAT-streptavidin into human cells. - BMC Biotechnol. 7(1):1 [C]
*Sultana, A., Alexeev, I., *Kursula, I., Mäntsälä, P., Niemi, J., and *Schneider G. 2007: Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning. - Acta Crystallographica D 63:149-159. [C]
Tammenkoski, M., *Moiseev, V.M., Lahti, M., *Ugochukwu, E., *Brondijk, T.H.C., *White, S.A., Lahti, R. & *Baykov, A.A. 2007: Kinetic and mutational analyses of the major cytosolic exopolyphosphatase from Saccharomyces cerevisiae. – J. Biol. Chem. 282: 9302-9311. [C]
Toriseva, M., Ala-aho, R., Karvinen, J., *Baker, A. H., *Marjomäki, V., Heino, J. and Kähäri, V.M. 2007: Collagenase-3 (MMP-13) enhances collagen gel contraction and cell survival in collagen by adult skin fibroblasts. - J Invest Dermatol 127: 49-59. [C]
Tulla, M., *Huhtala, M., *Jäälinoja, J., Käpylä, J., *Farndale, R.W., *Ala-Kokko, L., *Johnson, M.S. and Heino, J. 2007: Analysis of an ascidian integrin provides new insight into early evolution of collagen recognition. - FEBS Lett. 581: 2434-2440. [C]
*Upla, P., *Marjomäki, V., *Nissinen, L., Nylund, C., *Waris, M., Hyypiä, T., Heino J. 2007: Calpain 1 and 2 are required for the RNA replication of echovirus 1. - J Virol. 21. [C]
Vuoristo, M., Vihinen, P., Vlaykova, T., Nylund, C., Heino, J., Pyrhönen, S. 2007:
Increased gene expression levels of collagen receptor integrins are associated with decreased survival parameters in patients with advanced melanoma. - Melanoma Res. 17(4):215-23. [C]
*White, D., Kankaanpää, P., *Kutilainen, T. 2006: BioImageXD, New software for multidimensional image visualization, processing and analysis - CSC News, 4/2006: 29-31 [I]
Biokemian linja / Biochemistry 2006
Väitöskirjat / Doctoral theses 2006 [sivun alkuun / page top]
Hakkila, K. 2006: Metals and environment: Engineering of bacterial bioreporters for more specific metal detection. Annales Universitatis Turkuensis A I 355, 94 p.
Leskinen, P. 2006: Developing Yeast-Cell-Based Assays for Measuring Endocrine Disrupters in the Environment. Annales Universitatis Turkuensis A I 349, 86 p.
Muu tieteellinen julkaisutoiminta / Other scientific publications 2006
Airas, K. R. 2006: Analysis of the kinetic mechanism of arginyl-tRNA synthetase. - Biochimica et Biophysica Acta 1764: 307-319. [C]
*Beinker, P., *Lohkamp, B., Peltonen, T., Niemi, J., Mäntsälä, P. & *Schneider, G. 2006: Crystal Structures of SnoaL2 and AcIR: Two Putative Hydroxylases in the Biosynthesis of Aromatic Polyketide Antibiotics. - J Mol Biol 359: 728-740. [C]
*D’yakova, E.V., *Rakitin, A.L., *Kamionskaya, A.M., *Baikov, A.A., Lahti, R., *Ravin, N.V. & *Skryabin, K.G. 2006: A study of the effect of expression of the gene encoding the membrane H+ -pyrophosphatase of Rhodospirillum rubrum on salt resistance of transgenic tobacco plants. – Doklady Biological Sciences 409: 346-348. [C]
Hohenthal, U., Nuutila, J., Lilius, E.-M., Laitinen, I., Nikoskelainen, J. & Kotilainen, P. 2006: Measurement of complement receptor 1 on neutrophils in bacterial and viral pneumonia. - BMC Infectious Diseases 6:11. [C]
Kallio, P., *Sultana, A., Niemi, J., Mäntsälä, P. & *Schneider, G. 2006: Crystal Structure of the Polyketide Cyclase AknH with Bound Substrate and Product Analogue: Implications for Catalytic Mechanism and Product Stereoselectivity. - J Mol Biol 357: 210-220. [C]
Kankaanpää, P. 2006: Basics of confocal microscopy. Opetusmateriaali, 24 sivua. [i]
Kankaanpää, P. 2006: Studying virus infection with BioImageXD. Videoelokuva, n. 3 min. [J]
Kankaanpää, P., Pahajoki, K., *Marjomäki, V., Heino, J., *White, D. 2006: BioImageXD – New open source free software for the processing, analysis and visualization of multidimensional microscopic images. - Microscopy Today 14(3): 12-16. [E]
Kankaanpää, P., Pahajoki, K., *Marjomäki, V., Heino, J., *White, D. 2006: BioImageXD 0.9.0 beta. 9.2. [L]
Lehtinen, J., Järvinen, S., Virta, M. & Lilius, E-M. 2006: Real-time monitoring of antimicrobial activity with the multiparameter microplate assay. - J Microbiol Methods 66: 381-389. [C]
Lilius, E-M. & Lehtinen, J. 2006: Monitoring of bacteriostatic, bactericidic and bacteriolytic effects of antimicrobial agents on a real-time basis. In European conference on the reversal of multidrug resistance from bacteria to cancer cells and parasites, Closing conference of the COST Action B16. Conference proceedings, pp. 58-66. [D]
Lilius, E.-M. & Nuutila, J. 2006: Particle-induced myeloperoxidase release in serially diluted whole blood quantifies the number and the phagocytic activity of blood neutrophils and opsonization capacity of plasma. - Luminescence 21: 148-158. [C]
Lilius, E.-M. & Virta, M. 2005: Method to enable assessment of growth and death of Micro-organisms US 6,866,995 B1 [K]
Malinen, A. 2006: Biokemian harjoitustyöt, ß-galaktosidaasi. Opetusmoniste. 10 s. [i]
Malinen, A. 2006: Entsyymi- ja proteiinikemian harjoitustyöt, Membraaniproteiinit. Opetusmoniste. 11 s. [i]
Matilainen, H., Makela, A.R., Riikonen, R., Saloniemi, T., Korhonen, E., Hyypia, T., Heino, J., Grabherr, R., Oker-Blom, C. 2006: RGD motifs on the surface of baculovirus enhance transduction of human lung carcinoma cells. Journal of Biotechnology 125:114-26. [C]
Mirtti, T., Nylund, C., Lehtonen, J., Hiekkanen, H., Nissinen, L., Kallajoki, M., Alanen, K., Gullberg, D., Heino, J. 2006: Regulation of prostate cell collagen receptors by malignant transformation. - Int J Cancer 118: 889-98. [C]
Nikoskelainen, S., Kjellsen, O., Lilius, E.-M., Schroder, M.B. 2006: Respiratory burst activity of Atlantic cod (Gadus morhua L.) blood phagocytes differs markedly from that of rainbow trout. - Fish Shellfish Immunol. 21:199-208. [C]
Nuutila, J., Laitinen, I., Hohenthal, U., Kotilainen, P., Rajamäki, A., Nikoskelainen, J. & Lilius, E.-M. 2006: Complement receptor 1 (CR1/CD35) on human neutrophils as a marker of bacterial pneumonia. - Clinical Laboratory international, October issue: 8-9. [E]
Nuutila J., Laitinen I., Hohenthal U., Kotilainen P., Rajamäki A., Nikoskelainen J. & Lilius E.-M. 2006: Quantitative analysis of complement receptors, CR1 (CD35) and CR3 (CD11b), on neutrophils improves distinction between bacterial and viral infections in febrile patients: Comparison with standard clinical laboratory data. - J Immunol Methods 315: 191-201. [C]
Parikka, M., Nissinen, L., Kainulainen, T., Bruckner-Tuderman, L., Salo, T., Heino, J., Tasanen, K. 2006: Collagen XVII promotes integrin-mediated squamous cell carcinoma transmigration--a novel role for alphaIIb integrin and tirofiban. - Experimental Cell Research 312: 1431-8. [C]
Salminen, A., *Ilias, M., Belogurov, G., *Baykov, A.A., Lahti, R. & *Young, T. 2006: Two soluble pyrophosphatases in Vibrio cholerae: transient redundancy or enduring cooperation? – Biochemistry (Moscow) 71: 978-982. [C]
Biokemian linja / Biochemistry 2005
Väitöskirjat / Doctoral theses 2005 [sivun alkuun / page top]
Halonen, P. 2005: Metal-activated Phosphohydrolases: Soluble Inorganic Pyrophosphatase, a Case Study. Annales Universitatis Turkuensis A I 331, 149 p.
Kapetaniou, E. 2005: Crystallographic Studies of Enzyme Stability. Annales Universitatis Turkuensis A II 189, 144 p.
Muu tieteellinen julkaisutoiminta / Other scientific publications 2005
Belogurov, G, Malinen, A., *Turkina, M.V., Jalonen, U., Rytkönen, K., *Baykov, A.A. & Lahti, R. 2005: Membrane-bound pyrophosphatase of Thermotoga maritima requires sodium for activity. – Biochemistry 44: 2088-2096. [C]
W.L. Connors and J. Heino. 2005: A Duplexed Microsphere-Based Cellular Adhesion Assay. Analytical Biochem 337: 246-255. [C]
Halonen, P., Tammenkoski, M., Niiranen, L., Huopalahti, S., *Parfenyev, A.N., *Goldman, A., *Baykov, A.A. & Lahti, R. 2005: Effects of active site mutations on the metal binding affinity, catalytic competence, and stability of the family II pyrophosphatase from Bacillus subtilis. – Biochemistry 44: 4004-4010. [C]
J. Heino, *M. Vuento: Paljon tilaa pohjalla - johdatus nanotieteeseen ja nanoteknologiaan. WSOY, Porvoo, Finland, 2005. ISBN 951-0-30048-9. [h]
*M. Huhtala, J. Heino, *D. Casciari, *A. de Luice, and *M.S. Johnson. 2005: Integrin evolution: insights from ascidian and teleost fish genomes. Matrix Biology 24: 83-95. [C]
*Jansson A., *Koskiniemi H., *Erola A., *Wang J., Mäntsälä P., *Schneider G., Niemi J. 2005: Aclacinomycin-10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor. J. Biol. Chem., Feb 4; 280 (5): 3636-3644. [C]
Leskinen, P., *Michelini, E., *Picard, D., Karp, M., Virta, M. 2005. Bioluminescent yeast assays for detecting estrogenic and androgenic activity in different matrices. Chemosphere. 61(2):259-66. [C]
Lilius E-M. & Virta M. 2005: A method to enable assessment of growth and death of micro-organisms. Patent EP 1194586 B1 12.1.2005. [K]
*M.L. Linn, *J. Eble, *C. Lübken, *R.W. Slade, J. Heino, *J. Davies, and *A. Suhrbier. 2005: An arthritogenic alphavirus uses the a1ß1 integrin collagen receptor. Virology 336: 229-239. [C]
*Michelini, E., Leskinen, P., Virta, M., Karp, M., *Roda, A. 2005. A new recombinant cell-based bioluminescent assay for sensitive androgen-like compound detection. Biosens Bioelectron. 20(11):2261-7. [C]
*Michelini, E., *Magliulo, M., Leskinen, P., Virta, M., Karp, M., *Roda, A. 2005. Recombinant cell-based bioluminescence assay for androgen bioactivity determination in clinical samples. Clin Chem. 51(10):1995-8. [C]
Nikoskelainen, S., Verho, S., Airas, K. & Lilius, E.-M. 2005: Adhesion and ingestion activities of fish phagocytes induced by bacterium Aeromonas salmonicida can be distinguished and directly measured from highly diluted whole blood of fish. Dev Comp Immunol 29: 525-537. [C]
Nuutila, J. & Lilius, E.-M. 2005: Flow cytometric quantitative determination of
ingestion by phagocytes needs the distinguishing of overlapping populations of binding and ingesting cells. Cytometry Part A; 65A: 93-102. [C]
*V. Pietiäinen, *V. Marjomäki, J. Heino, and T. Hyypiä. 2005: Virus entry in caveolae and rafts. Ann Med 37: 394-403. [F]
Rappu, P., Leppihalme, M., Mäntsälä, P. 2005: Mutational Analysis of the Bacillus subtilis purA Operator Site. Current Microbiology 51: 322-326. [C]
*R. Riikonen, *H. Matilainen, *N. Rajala, *O. Pentikäinen, *M. Johnson, J. Heino, and *C. Oker-Blom. 2005: Functional display of an alpha2 integrin-specific motif (RKK) on the surface of baculovirus particles. Technol Cancer Res Treat. 4: 437-445. [C]
Soilu-Hanninen M., Koskinen J.O., Laaksonen M., Hanninen A., Lilius E-M., Waris M. 2005: High sensitivity measurement of CRP and disease progression in multiple sclerosis. Neurology. 65: 153-155. [C]
Tammenkoski, M., *Benini, S, *Magretova, N.N., *Baykov, A.A., Lahti, R. 2005: An Unusual, His-Dependent Family I Pyrophosphatase from Mycobacterium tuberculosis. – J. Biol. Chem. 280: 41819-41826. [C]
Verho, S., Järvinen, S., Nikoskelainen, S. & Lilius, E.-M. 2005: Biological effect of vaccination can be assessed directly from diluted whole blood of rainbow trout using homologous blood phagocytes as immunosensors. Fish Shellfish Immunol 19: 175-183. [C]
*Zyryanov, A.B., Lahti, R. & *Baykov, A.A. 2005: Inhibition of family II pyrophosphatases by analogs of pyrophosphate and phosphate.– Biochemistry (Moscow) 70: 908-912. [C]
Biokemian linja / Biochemistry 2004
Väitöskirjat / Doctoral theses 2004 [sivun alkuun / page top]
Belogurov, G. 2004: Pyrophosphate-energized proton pumps: identification of the residues determining K+ requirements and discovery of a Na+-dependent enzyme. Annales Universitatis Turkuensis, Ser. A1; Tom. 327: 76 p.
Hietakangas, V. 2003: Posttranslational regulation involved in HSF1- and HSF2 –mediated transcription. Annales Universitatis Turkuensis, Ser. A1; Tom. 311: 138 p.
Nummelin, H. 2004: The structure of Yersinia adhesin a collagen-binding domain. Annales Universitatis Turkuensis, Ser. A1; Tom. 325: 101 p.
Nuutila, J. 2003: Interrelations between receptor expression, respiratory burst, and phagocytosis (monografia). Annales Universitatis Turkuensis, Ser. A1; Tom. 313: 127 p.
Peltoniemi, K. 2004: Molecular Genetic Characterisation of an Oligopeptide Transport System from Lactobacillus delbrueckii subsp. bulgaricus and Some Key Peptidases from Lactobacillus helveticus. Annales Universitatis Turkuensis, Ser. A1; Tom. 317: 118 p.
Rappu, P. 2004: De Novo Purine Nucleotide Biosynthesis in Gram-positive Bacteria: Regulation of Bacillus subtilis purA Encoding Adenylosuccinate Synthetase. Annales Universitatis Turkuensis, Ser. A1; Tom. 320: 108 p.
Wahlroos, T. 2004: Modification of histidine content in transgenic Brassica Rapa plants. Annales Universitatis Turkuensis, Ser. A1; Tom. 323: 76 p.
Muu tieteellinen julkaisutoiminta / Other scientific publications 2004
Belogurov, G.A., *Baykov, A.A. & Lahti, R. (2004). H+-PPase homolog from Thermotoga maritima. Expression in E. coli and steady-state kinetic analysis of the effects of alkali cations on pyrophosphatase activity. Recent Advances in Inorganic Pyrophosphatase Research (Ed. Scott A. White), p. 65, University of Birmingham, Birmingham, UK, ISBN 0704424738. [D]
*Chen, D., *Roberts, R., *Pohl, M., *Nigam, S., *Kreidberg, J., *Wang, Z., Heino, J., Ivaska, J., *Coffa, S., *Harris R.C., *Pozzi, A. and *Zent, R. (2004). Differential expression of collagen and laminin binding integrins mediate ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol 287: F602-611. [C]
*Fabrichniy, I.P., *Lehtiö, L., Salminen, A., *Baykov, A.A., Lahti, R. & *Goldman, A. (2004). Structural studies of metal ions in family II pyrophosphatases: The requirement for a Janus ion. Biochemistry 43: 14403-14411. [C]
Hakkila, K., *Green, T., Leskinen, P., *Ivask, A., *Marks, R. & Virta, M. (2004). Detection of bioavailable heavy metals in EILATox-Oregon samples using whole-cell luminescent bacterial sensors in suspension or immobilized into fibre-optic tips. Journal of Applied Toxicology 24: 333-342. [C]
Hakkila, K., *Lappalainen, J. & Virta, M. (2004). Toxicity detection from EILATox-Oregon workshop samples by using kinetic photobacteria measurement: the flash method. Journal of Applied Toxicology 24: 349-353. [C]
Halonen, P., Tammenkoski, M., Niiranen, L., Huopalahti, S., *Parfenyev, A.N., *Baykov, A.A. & Lahti, R. (2004). Effects of active site mutations on the metal binding affinity, catalytic competence, and stability of Bacillus subtilis inorganic pyrophosphatase. Recent Advances in Inorganic Pyrophosphatase Research (Ed. Scott A. White), pp. 45-47, University of Birmingham, Birmingham, UK, ISBN 0704424738. [D]
Heino, J., Vuento, M.: Solubiologia. WSOY, Porvoo, Finland. Toinen uudistettu painos (2004) ISBN 951-0-28955-8. [h]
*Häkkinen, L., Koivisto, L., *Gardner, H., *Saarialho-Kere, U., *Carroll, J., *Lakso, M., *Rauvala, H., Laato, M., Heino, J. and *Larjava, H. (2004). Increased expression of beta-6 integrin in skin leads to spontaneous development of chronic wounds. Am J Pathol 164: 229-242. [C]
*Jansson, A., Koskiniemi, H., Mäntsälä, P., Niemi J., *Schneider, G. (2004). Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products. J Biol Chem Sep 24;279(39): 41149-41156. [C]
*Jokinen, J., *Dadu, E., Nykvist, P., *Käpylä, J., *White, D.J., Ivaska, J., *Vehviläinen, P., *Reunanen, H., *Larjava, H., *Häkkinen, L. and Heino, J. (2004). Integrin-mediated cell adhesion to type I collagen fibrils. J Biol Chem. 279: 31956-31963. [C]
Koistinen, P., Ahonen, M., Kähäri, V.M. and Heino, J. (2004). aV Integrin promotes in vitro and in vivo survival of cells in metastatic melanoma. Int J Cancer 112:61-70. [C]
*Käpylä, J., *Jäälinoja, J., *Tulla, M., *Ylöstalo, J., Nissinen, L., *Viitasalo, T., Säämänen, A.M., *Vehviläinen, P., *Marjomäki, V., *Farndale, R.W., *Birk, D., *Ala-Kokko, L., and Heino, J. (2004). The fibril associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix. J Biol Chem 279: 51677-51687. [C]
Lehtinen J., Nuutila J., Lilius E-M. (2004). Green Fluorescent Protein-Propidium Iodide (GFP-PI) Based Assay for Flow Cytometric Measurement Bacterial Viability. Cytometry 60A: 165-172. [C]
Malinen, A.M., Belogurov, G.A., Salminen, M., *Baykov, A.A. & Lahti, R. (2004). Elucidating the role of conserved glutamates in H+-pyrophosphatase of Rhodospirillum rubrum. J. Biol. Chem. 279: 26811-26816. [C]
Malinen, A., Belogurov, G., Salminen, M., *Baykov, A.A. & Lahti, R. (2004). Substitutions of conserved glutamates in H+-pyrophosphatase of Rhodospirillum rubrum cause multiple functional defects. Recent Advances in Inorganic Pyrophosphatase Research (Ed. Scott A. White), pp. 60-62, University of Birmingham, Birmingham, UK, ISBN 0704424738. [D]
Metsä-Ketelä, M., *Ylihonko, K., Mäntsälä, P. (2004). Partial Activation of a Silent Angucycline-type Gene Cluster from a Rubromycin Beta Producing Streptomyces sp. PGA64. Journal of Antibiotics 57(8): 502-510. [C]
Nikkola-Paakkarinen, J., Vihinen, P., Vlaykova, T., Hahka-Kemppinen, M., Heino, J. and Pyrhönen, S. (2004). Integrin chains ?????and ???V as prognostic markers in human metastatic melanoma. Melanoma Research 14: 29-37. [C]
Nikoskelainen S., Bylund G., Lilius E-M. (2004). Effect of environmental temperature on rainbow trout (Oncorhynchus mykiss) immunity. Developmental & Comparative Immunology 28: 581-592. [C]
Nikoskelainen S., Nuutila J., Laitinen, I., Lehtinen J., Kilpi M., Eerola L., Airio M. and Lilius E-M. (2004). Luminescence and Radioactivity Detection Limits of HIDEX Plate CHAMELEON™. Application note DOC 412-010. (E)
Nikoskelainen S., Nuutila J., Lilius E-M. (2004). Luminescence and Flow-Cytometry Applications for Fish Immunology. University of Turku. (E)
Nikoskelainen S. Ouwehand A.C., Salminen S., Bylund G., Lilius E-M. (2004). Trout healt gets a boost from probiotic Lactobacillus. Feed Mix 12: 18-21. (C)
*Nymalm, Y., *Puranen, J.S., *Nyholm, T.K.M., *Käpylä, J., *Kidron, H., *Pentikäinen, O.T., *Airenne, T.T., Heino, J., *Slotte, J.P., *Johnson, M.S., and *Salminen T.A. (2004). Jararhagin-derived RKKH-peptides induce structural changes in ???? I domain of human integrin ??????????J Biol Chem 279: 7962-7970. [C]
Salminen, A., *Ilias, M., *Baykov, A.A., Lahti, R. & *Young, T. (2004). Does Vibrio cholerae synthesise both family I and family II inorganic pyrophosphatases? Recent Advances in Inorganic Pyrophosphatase Research (Ed. Scott A. White), pp. 18-19, University of Birmingham, Birmingham, UK ISBN 0704424738. [D]
*Sultana, A., Kallio, P., *Jansson, A., *Wang, J-S., Niemi, J., Mäntsälä, P. and *Schneider, G. (2004). Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis. Acta Crystallogr. D Biol. Crystallogr. 60: 1118- 2000. [C]
*Sultana, A., Kallio, P., *Jansson, A., *Wang, J-S., Niemi, J., Mäntsälä, P. and *Schneider, G. (2004). Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation. EMBO J. 23: 1911-1921. [C]
Tuominen, V.U., *Myles, D.A.A., *Dauvergne, M.-T., Lahti, R., Heikinheimo, P. & *Goldman, A. (2004). Production and preliminary analysis of perdeuterated yeast inorganic pyrophosphatase crystals suitable for neutron differaction. Acta Cryst. D 60: 606-609. [C]
*Upla, P., *Marjomäki, V., *Kankaanpää, P., Ivaska, J., Hyypiä, T., *van der Goot, F.G. and Heino, J. (2004). Clustering induces a lateral redistribution of ???????? integrin from membrane rafts to caveolae and PKC-dependent internalization. Mol Biol Cell 15:625-636. [C]
Väisänen M., Lilius E-M., Mustonen L., Raekallio M., Kuusela E., Koivisto M., Vainio O. (2004). Effects of ovariohysterectomy on canine blood neutrophil respiratory burst: a chemiluminescence study. Vet. Surg. 33: 551-556. [C]
*White, D.J., *Puranen, S., *Johnson, M.S., and Heino, J. (2004). The collagen receptor subgroup of integrins. Int J Biochem Cell Biol. 36: 1405-1410. (F)
*Xing, L., *Huhtala, M., *Pietiäinen, V., *Käpylä, J., *Vuorinen, K., *Marjomäki, V., Heino, J., *Johnson, M.S., Hyypiä, T., and *Cheng; R.H. (2004). Structural and functional analysis of integrin ????I domain interaction with echovirus 1. J Biol Chem 279: 11632-11638. [C]
*Zhang, L., Koivisto, L., Heino, J., and *Uitto, V.J. (2004). Bacterial heat shock protein 60 may increase epithelial cell migration through activation of MAP kinases and inhibition of alpha6beta4 integrin expression. Biochem Biophys Res Commun. 319: 1088-1095. [C]
*Zimenkov, Y.V., Salminen, A., *Efimova I.S., Lahti, R. & *Baykov, A.A. (2004). Cd2+-induced aggregation of Escherichia coli pyrophosphatase. Eur. J. Biochem. 271: 3064-3067. [C]
*Zyryanov, A.B., Tammenkoski, M., Salminen, A., *Kolomiytseva, G.Y., *Fabrichniy, I.P., *Goldman, A., Lahti, R. & *Baykov, A.A. (2004). Site-specific Effects of Zinc on the Activity of Family II Pyrophosphatase. Biochemistry 43: 14395-14402. [C]
*Zyryanov, A.B., *Vener, A.V., Salminen, A., *Goldman, A., Lahti, R. & *Baykov, A.A. (2004). Rates of elementary catalytic steps for different metal forms of the family II pyrophosphatase from Streptococcus gordonii. Biochemistry 43: 1065-1074. [C]
Biokemian linja / Biochemistry 2003
Väitöskirjat / Doctoral theses 2003 [sivun alkuun / page top]
Erkkilä, Maria. Genetic variation of Barley ß-amylase gene expressed in grain. Turun ylipisto, Typopress Oy, Turku, 95 p. 2003.
Hietakangas, Ville. Posttranslational regulation involved in HSF1- and HSF2-mediated transcription. Turun yliopisto, Painosalama Oy, Turku, 138 p. 2003.
Metsä-Ketelä, Mikko. Harnessing the Potential for Antibiotic Production within Streptomyces Genomes: from Gene Detection to Antibiotic Production. Turun yliopisto, Gillot Oy, Turku, 131 p. 2003.
Nuutila, Jari. Interrelations between receptor expression, respiratory burst, and phagocytosis. Turun yliopisto, Painosalama Oy, Turku, 127 p. 2003.
Muu tieteellinen julkaisutoiminta / Other scientific publications 2003
*Bartus, C.L., *Jaakola, V.-P., *Reusch, R., *Valentine, H.H., Heikinheimo, P., *Levy, A., *Potter, L.T., *Heimo, H., *Goldman, A. & *Turner, G. (2003) Downstream coding region determinants of bacterio-opsin, muscarinic acetylcholine receptor and adrenergic receptor expression in Halobacterium salinarum. Biochim Biophys Acta 1610:109-123. (C)
*Belyaev, S., *Himanen, J.-P., Korpela, T., Mäkelä, M. & Susi, P. (eds) 2003. Proceedings of the First Symposium on ??Current Trends of Biotechnology in Finland and Japan??. Turku/Helsinki, Finland. 15.-20.9.2002. (G)
*Hautala, A., *Torkkell, S., Räty, K., *Kunnari, T., *Kantola, J., Mäntsälä, P., *Hakala, J. and *Ylihonko, K. (2003) Studies on a second and third ring cyclization in anthracycline biosynthesis. J. Antibiot. 56:143-153 (C)
Hietakangas, V., *Ahlskog, J.K., *Jakobsson, A.M., *Hellesuo, M., *Sahlberg, N.M., *Holmberg, C.I., *Mikhailov, A., *Pirkkala, L. and *Sistonen, L. (2003) Phosphorylation of of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol. Cell Biol. 23:2953-2968 (C)
Hietakangas, V., *Poukkula, M., *Heiskanen, K.M., *Karvinen, J.T., *Sistonen, L. and *Eriksson, J. (2003) Erythroid differentation sensitizes K562 leukemia cells to trail-induced apoptosis by downregulation of c-FLIP. Mol. Cell Biol. 23:1278-1291 (C)
Hohkuri, M., Wahlroos, T. & Susi, P. (2003) RNA-hiljentyminen. Solubiologi 21:10-16. (e)
*Ihalin, R., Nuutila, J., *Loimaranta, V., *Lenander, M., *Tenovuo, J. & Lilius, E.-M. (2003) Susceptibility of Fusobacterium nucleatum to killing by peroxidase-iodide-hydrogen peroxide combination in buffer solution and in human whole saliva. Anaerobe 9:23-30. (C)
*Jansson, A., Niemi, J., *Lindqvist, Y., Mäntsälä, P. and *Schneider, G. (2003) Crystal structure of aclacinomycin-10-hydroxylase, a S-adenosylmethionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens. J. Mol Biol. 334(2):269-280 (C)
*Jansson, A., Niemi, J., Mäntsälä, P. and *Schneider, G.(2003) Crystallization and preliminary X-ray diffraction studies on aclacinomycin-10-methyl esterase and aclacinomycin-10-hydroxylase from Streptomyces purpurascens. Acta Crystallogr. D Biol Crystallogr. 59:1637-1639 (C)
*Jansson, A., Niemi, J., Mäntsälä, P. and *Schneider, G.(2003) Crystal structure of aclacinomycin methylesterase with bound product analoques: implications for anthracycline recognition and mechanism J. Biol. Chem. 278(40):39006-39013 (C)
*Kantola, J., *Kunnari, T., Mäntsälä, P. and *Ylihonko, K. (2003) Expanding the scope of aromatic polyketides by combinatorial biosynthesis. Comb. Chem. High Throughput Screen. 6:501-512 (F)
*Karger, E.M., *Frolova, O.Yu., *Fedorova, N.V., *Baratova, L.A., *Ovchinnikova, T.V., Susi, P., *Mäkinen, K., *Ronnstrand, L., *Dorokhov, Yu.L. & *Atabekov, J.G. (2003) Dysfunctionality of a tobacco mosaic virus movement protein mutant mimicking threonine 104 phosphorylation. Journal of General Virology 84:727-732. (C)
*Khalikova, E., Susi, P., *Usanov, N. & Korpela, T. (2003) Purification and properties of extracellular dextranase from a Bacillus sp. Journal of Chromatography B 796:315-326. (C)
Lehtinen, J., Virta, M. & Lilius, E.-M. (2003) Fluoro-luminometric real-time measurement of bacterial viability and killing. J Microbiol Methods 55:173-186. (C)
Lilius, E.-M. & Nuutila, J. (2003) Method for determining the nature of an infection. Patent publication PCT/FI02/00472 WO 02/099433. (K)
*Lojek, A., *Ciz, M., *Kubala, L., Nuutila, J. & Lilius, E.-M. (2003) Chemiluminescence of isolated human leukocytes induced by Streptococcus mutans is generated extracellularly in the absence of phagocytosis. In: Bioluminescence and Chemiluminescence: Progress & Current Applications. (eds. P.E. Stanley & L.J. Kricka). World Scientific Publishing Co., Singapore 269-272. (C)
*Lunden, T., Lilius, E.-M. & *Bylund, G. (2003) Influence of trimethoprim and sulfadiazine on the immune response of rainbow trout (Oncorhynchus mykiss). Veterinary Immunology and Immunopathology 85:99-108. (C)
Metsä-Ketelä, M., Palmu, K., *Kunnari, T., *Ylihonko, K. and Mäntsälä, P. (2003) Engineering antharacycline biosynthesis toward angucyclines. Antimicrob. Agents & Chemother. 47(4):1291-1296 (C)
Nikoskelainen, S., Ouwehand, A., *Bylund, G., Salminen, S. & Lilius, E.-M. (2003) Immune enhancement in rainbow trout (Oncorhynchus mykiss) by a probiotic Lactobacillus rhamnosus. Fish & Shellfish Immunology 15:443-452. (C)
*Oikonen, M., *Laaksonen, M., *Laippala, P., *Oksaranta, O., Lilius E.-M., *Lindgren, S., *Rantio-Lehtimäki, A., *Anttinen, A., *Koski, K., *Erälinna, J.-P. (2003) Ambient Air Quality and Occurrence of Multiple Sclerosis Relapse. Neuroepidemiology 22:95-99. (C)
Rappu, P., Pullinen, T. and Mäntsälä, P. (2003) In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor. J. Bacteriol. 185(22):6728-6731 (C)
Wahlroos, T., Susi, P., *Tylkina, L., *Malyshenko, S., *Zvereva, S. & Korpela, T. (2003) Agrobacterium-mediated transformation and stable expression of the green fluorescent protein in Brassica rapa. Plant Physiology and Biochemistry 41:773-778. (C)
Biokemian linja / Biochemistry 2002
Väitöskirjat / Doctoral theses 2002 [sivun alkuun / page top]
Wang, Yulong 31.1.2002 Tailoring of aclacinomycin antibiotics by aklavinone-11-hydroxylase (RdmE) aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens
Salminen, Anu 16.5.2002 Discovery of a new family of souble pyrphosphatases and the functional role of quaternary structure in pyrophosphatases
Muu tieteellinen julkaisutoiminta / Other scientific publications 2002
Belogurov, G. A. & Lahti, R. (2002) A lysine substitute for K+. A460K mutation eliminates K+ dependence in H+-pyrophosphatase of Carboxydothermus hydrogenoformans. J. Biol. Chem. 277, 49651-49654. [C]
Belogurov, G.A., *Turkina, M.V., Penttinen, A., Huopalahti, S., *Baykov, A. A. & Lahti, R. (2002) H+-pyrophosphatase of Rhodospirillum rubrum: High-yield expression in Escherichia coli and identification of the cys residues responsible for inactivation by mersalyl J. Biol. Chem. 277, 22209-22214. [C]
Denesyuk, A., *Denessiouk, K., Korpela, T. and *Johnson, M. Functional attributes of the phosphate group binding cup of pyridoxal phosphate-dependent enzymes. (2002) J. Mol. Biol. 316, 155-172. [C]
Halonen, P., *Baykov, A.A., *Goldman, A., Lahti, R. & *Cooperman, B.S. (2002) Single-turnover kinetics of Saccharomyces cerevisiae inorganic pyrophosphatase. Biochemistry 41, 12025-12031. [C]
*Lundén, T, Lilius, E-M, and *Bylund,. Respiratory burst activity of rainbow trout (Oncorhynchus mykiss) phagocytes is modulated by antimicrobial drugs. Aquaculture 207 (2002):205-212. [C]
Metsä-Ketelä, M., *Halo, L., Munukka, E., *Hakala, J., Mäntsälä, P. and *Ylihonko, K. (2002) Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S rDNA genes from various Streptomyces species. Applied and Environmental Microbiology 68:4472-4479 [C]
Niemi J., *Kantola J., *Ylihonko K., and Mäntsälä P. Anthracycline biosynthesis: steps, enzymes and genes. In: Fierro F and Martin J F (eds)"Microbial Secondary Metabolites: Biosynthesis, Genetics and Regulation", Research Signpost, Kerala, India, 2002 20 sivua [F]
Nikoskelainen S, Lehtinen J, Lilius E-M: Bacteriolytic activity of rainbow trout (Oncorhynchus mykiss) complement. Developmental & comparative Immunology (2002);26:797-804. [C]
*M.J. Paape, *P.M. Rautiainen, E.M.Lilius, *C.E. Malstrom & *T.H.Elsasser, Development of anti-bovine TNF-??? mAb and ELISA for quantitating TNF-??? in milk after intramammary injection of endotoxin. J. Dairy Sci. 85 (2002): 765-773. [C]
Räty, K., *Hautala, A., Torkkell, S., *Kantola, J., Mäntsälä, P., *Hakala, J. and *Ylihonko, K. (2002) Characterization of mutations in aclacinomycin A-non-producing Streptomyces galilaeus strains with altered glucosylation pattern. Microbiology 148:3375-3384 [C]
Räty, K., *Kantola, J., *Hautala, A., *Hakala, J., *Ylihonko, K., and Mäntsälä, P. (2002) Cloning and characterization of Streptomyces galilaeus aclacinomycins PKS cluster. Gene 293:115-122 [C]
Salminen, A., *Parfenyev, A. N., Salli, K., *Efimova, I. S., *Magretova, N. N., *Goldman, A., *Baykov, A. A. & Lahti, R. (2002) Modulation of dimer stability in yeast pyrophosphatase by mutations at the subunit interface and ligand binding to the active site. J. Biol. Chem. 277, 15465-15471. [C]
Sareila, O., Wahlroos, T., Hohkuri, M. & Susi, P. 2002. Kasvivirusten liikkuminen ja kuvantaminen reaaliajassa fluoresoivia proteiineja käyttäen. Solubiologi 20, 12-18. [e]
Susi, P., Sareila, O. & Wahlroos, T. 2002. Visualization of plant virus movement by fluorescence and confocal laser scanning microscopy. Keränen, J. and Sillanpää K. (Eds.) Proceedings of the 53th Annual meeting of The Scandinavian Society for Electron Microscopy (ISSN 1455-4518). Sivut 88-89. [D]
Wang,Y., Niemi, J. and Mäntsälä, P. (2002) Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products. FEMS Microbiol. Lett. 208:117-122 [C]
Zavialov, A. V., Kersley, J., Korpela, T., Zav’yalov V. P., MacIntyre S. and Knight S. D. (2002) Assembly of Yersinia pestis F1 antigen produces a linear polymer and requires an intact N-terminal donor strand. Molecular Microbiology. 45(4):983-995 [C]
*Zyryanov, A.B., *Shestakov, A.S., Lahti, R. & *Baykov, A.A. (2002) Mechanism by which metal cofactors control substrate specificity in pyrophosphatase. Biochem. J 367, 901-906. [C]